tirzepatide for maintenance the of Body Weight Reduction: Rationale, Design, and Baseline Characteristics of SURMOUNT‐MAINTAIN Staying on a Tirzepatide Maintenance

At the cellular level, coptisine exerts dose-dependent cytotoxicity in HepG2 and 3T3-L1 cells, with IC 50 values of 64.81 g/mL and 56.48 g/mL, respectively, showing cytotoxicity only at relatively high concentrations (Yi et al., 2013)

For atorvastatin, the 2018 AHA/ACC Cholesterol Guideline recommends a fasting lipid panel 4 to 12 weeks after initiation or dose change, then every 3 to 12 months [12]

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Sotagliflozin, referred to as a dual SGLT1/2 inhibitor, has the highest affinity for SGLT1 (Markham and Keam, 2019), while canagliflozin can act as a dual SGLT1/2 inhibitor and is able to inhibit intestinal glucose absorption by blocking intestinal SGLT1 (Dominguez Rieg and Rieg, 2019)